The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of
ovarian carcinomas. Two general strategies have been developed for the targeted delivery …

Liposomes are being increasingly utilized to deliver drugs, enzymes, antisense
oligonucleotides, and genes to various therapeutic targets. Liposome-mediated delivery of …

Folic acid, attached to polyethyleneglycol-derivatized, distearoyl-phosphatidylethanolamine,
was used to target in vitro liposomes to folate receptor (FR)-overexpressing tumor cells …

Liposomal gene therapy vectors that penetrate cells by endocytosis must escape an
endosomal compartment in order to enter the target cell's nucleus. Because such …

A DTPA− folate conjugate was radiolabeled with 99mTc by stannous chloride reduction of
[99mTc] sodium pertechnetate in an aqueous solution of DTPA− folate. The radiochemical …

Abstract Konda SD, Aref M, Brechbiel M, Wiener EC. Development of a tumor-targeting MR
contrast agent using the high-affinity folate receptor: Work in progress. Invest Radiol 2000; …

Antisense oligonucleotides can be successfully employed to inhibit specifically gene
expression. However, many oligonucleotide classes are polyanions and cannot passively …

The development of methods for specific delivery of therapeutic genes into target tissues is
an important issue for the further progress of in vivo gene therapy. In this article we report on …

Folate receptor (FR) type β is expressed in the myelomonocytic lineage, predominantly
during neutrophil maturation and in myeloid leukemias. FR-β expression was elevated up to …

Liposome-encapsulated anticancer drugs reveal their potential for increased therapeutic
efficacy and decreased nonspecific toxicities due to their ability to enhance the delivery of …