Personality and polymorphisms of genes involved in aminergic neurotransmission

RP Ebstein, J Benjamin, RH Belmaker - European journal of pharmacology, 2000 - Elsevier
Genetic factors significantly contribute to the determination of human personality traits
assessed by self-report questionnaires. However, only in the past few years have common …

Recent progress in psychiatric genetics—some hope but no hype

SF Stoltenberg, M Burmeister - Human molecular genetics, 2000 - academic.oup.com
The reputation of the field of psychiatric genetics has recently become tarnished in the view
of many human geneticists. Too many linked loci were claimed and withdrawn, too many …

Evidence of a schizotypy subtype in OCD

C Sobin, ML Blundell, F Weiller, C Gavigan… - Journal of psychiatric …, 2000 - Elsevier
OCD patients represent a heterogeneous mix of clinical phenotypes, likely reflecting a wide
range of genetic vulnerabilities. In other medical illnesses, neurobiologically-based traits …

Exploratory association study between catechol‐O‐methyltransferase (COMT) high/low enzyme activity polymorphism and hypnotizability

P Lichtenberg, R Bachner‐Melman… - American Journal of …, 2000 - Wiley Online Library
Only recently have studies of electrocortical activity, event‐related potentials, and regional
cerebral blood flow begun to shed light on the anatomical and neurobiological …

Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family‐based haplotype relative risk study

R Horowitz, M Kotler, E Shufman… - American journal of …, 2000 - Wiley Online Library
A previous case control study by Vandenbergh et al.[1997: Am J Med Genet 74: 439–442]
showed an association between the high activity catechol O-methyltransferase (COMT) …

Association between homozygosity at the COMT gene locus and obsessive compulsive disorder

KM Schindler, MA Richter, JL Kennedy… - American journal of …, 2000 - Wiley Online Library
A functional polymorphism in the coding region of the catechol O-methyltransferase (COMT)
gene has been reported in previous studies to be associated with obsessive compulsive …

An interaction between the catechol O-methyltransferase and serotonin transporter promoter region polymorphisms contributes to tridimensional personality …

J Benjamin, Y Osher, P Lichtenberg… - …, 2000 - karger.com
Persistence (RD2) is a subscale of the reward dependence trait, one of the three major
personality factors assessed by the Tridimensional Personality Questionnaire (TPQ) …

Genetic and imaging strategies in obsessive–compulsive disorder: potential implications for treatment development

DR Rosenberg, GL Hanna - Biological psychiatry, 2000 - Elsevier
In recent years, advances in brain research have resulted in a striking strategic shift in
studies designed to develop new, effective treatments for neuropsychiatric disorders. This …

An association study between 5-HTTLPR polymorphism, COMT polymorphism, and Tourette's syndrome

MC Cavallini, D Di Bella, M Catalano, L Bellodi - Psychiatry research, 2000 - Elsevier
Several lines of evidence suggest that a genetic component underlies Tourette's syndrome
(TS). We investigated both the role of the insertion/deletion polymorphism in the promoter …

Personality traits and smoking in patients with obsessive-compulsive disorder

S Bejerot, L von Knorring, L Ekselius - European psychiatry, 2000 - cambridge.org
As opposed to other psychiatric populations, subjects with obsessive-compulsive disorder
(OCD) smoke less than the general population. The present study aims at further …