The role of the locus coeruleus in the development of Parkinson's disease
M Gesi, P Soldani, FS Giorgi, A Santinami… - Neuroscience & …, 2000 - Elsevier
In Parkinson's disease, together with the classic loss of dopamine neurons of the substantia
nigra pars compacta, neuropathological studies and biochemical findings documented the …
nigra pars compacta, neuropathological studies and biochemical findings documented the …
Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling
WG Tatton, RME Chalmers-Redman, M Elstner… - Advances in Research …, 2000 - Springer
Summary Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a well-studied
glycolytic enzyme that plays a key role in energy metabolism. GAPDH catalyzes the …
glycolytic enzyme that plays a key role in energy metabolism. GAPDH catalyzes the …
The parkinsonian toxin MPTP: action and mechanism
S Przedborski, V Jackson-Lewis… - Restorative …, 2000 - content.iospress.com
MPTP causes damage to substantia nigra pars compacta (SNpc) dopaminergic (DA)
neurons as seen in Parkinsons disease (PD). After sys-temic administration of MPTP, its …
neurons as seen in Parkinsons disease (PD). After sys-temic administration of MPTP, its …
Dendrite loss is a characteristic early indicator of toxin-induced neurodegeneration in rat midbrain slices
PT Bywood, SM Johnson - Experimental neurology, 2000 - Elsevier
In rat brain substantia nigra catecholamine neurons in vitro, a sensitive indicator of excitatory
amino-acid-induced damage is dendritic degeneration that precedes the loss of the cell …
amino-acid-induced damage is dendritic degeneration that precedes the loss of the cell …
Acute ultrastructural effects of MPTP on the nigrostriatal pathway of the C57BL/6 adult mouse: evidence of compensatory plasticity in nigrostriatal neurons
JA Cochiolo, R Ehsanian… - Journal of Neuroscience …, 2000 - Wiley Online Library
Abstract Acute doses of 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP) elicited
degenerative and apparently compensatory changes in the nigrostriatum of injected animals …
degenerative and apparently compensatory changes in the nigrostriatum of injected animals …
Calpain upregulation in spinal cords of mice with 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP)‐induced Parkinson's disease
SK Ray, GG Wilford, SF Ali… - Annals of the New York …, 2000 - Wiley Online Library
Methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP), a heroin analogue, is a neurotoxin
that undergoes in vivo oxidation by monoamine oxidase‐B (MAO‐B) to 1‐methyl‐4 …
that undergoes in vivo oxidation by monoamine oxidase‐B (MAO‐B) to 1‐methyl‐4 …
Loss of tyrosine hydroxylase immunoreactivity in dendrites is a sensitive index of kainic acid-induced damage in rat substantia nigra neurons in vivo
PT Bywood, SM Johnson - Neuroscience letters, 2000 - Elsevier
An early indicator of damage to substantia nigra dopamine neurons in vitro is loss of
dendrites that precedes loss of the cell body. To investigate dendritic damage in vivo, rats …
dendrites that precedes loss of the cell body. To investigate dendritic damage in vivo, rats …
Advances in our knowledge of MPTP action and mechanism
S Przedborski - Neurotoxic Factors in Parkinson's Disease and Related …, 2000 - Springer
MPTP causes damage to substantia nigra pars compacta (SNpc) dopaminergic (DA)
neurons as seen in Parkinson's disease (PD). After systemic administration of MPTP, its …
neurons as seen in Parkinson's disease (PD). After systemic administration of MPTP, its …