▪ Abstract The ability of pathogens to obtain iron from transferrins, ferritin, hemoglobin, and
other iron-containing proteins of their host is central to whether they live or die. To combat …

Diphtheria toxin (DT) is an extracellular protein of Corynebacterium diphtheriae that inhibits
protein synthesis and kills susceptible cells. The gene that encodes DT (tox) is present in …

Mycobacterium tuberculosis can persist in an altered physiological state for many years after
initial infection, and it may reactivate to cause active disease. An analogous persistent state …

The alternate RNA polymerase sigma factor gene, sigF, which is expressed in stationary
phase and under stress conditions in vitro, has been deleted in the virulent CDC1551 strain …

Rhodanese is an ubiquitous enzyme that in vitro catalyses the transfer of a sulfur atom from
suitable donors to nucleophilic acceptors by way of a double displacement mechanism …

A bank of 600 insertional mutants of Mycobacterium smegmatis was screened for mutants
defective in stationary-phase survival. Of 74 mutants picked by the initial screen, 21 had …

The expression of diphtheria toxin is controlled by the diphtheria toxin repressor (DtxR).
Under conditions of high iron concentration, DtxR binds the tox operator to inhibit …

Iron acquisition is one of the important virulence characteristics of a pathogen.
Microorganisms elaborate different ways of acquiring iron. Siderophore-mediated iron …

The diphtheria toxin repressor (DtxR) of Corynebacterium diphtheriae uses Fe2+ as a
corepressor. Holo-DtxR inhibits transcription from the iron-regulated promoters (IRPs) …

Abstract The Bcg/lty/Lsh locus confers natural host resistance to mice infected with several
unrelated species ofintracellular pathogens. The Nrampl gene was identified by Vidal and …