The gradual recovery of activity of serotonergic neurons following an initial inhibition has
been hypothesized to play an important role in the delayed onset of efficacy of selective …

The influence of the 5-hydroxytryptamine 1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin
(DPAT) on locomotor hyperactivity induced by the acute and chronic administration of …

Presynaptic receptor theory has been expanded to encompass the regulation of the firing
rate of serotonergic neurons through negative feedback mediated by the somadendritic …

In the first experiment, separate groups of rats (n= 7) were treated with either saline, cocaine
(10 mg/kg), haloperidol (0.1 mg/kg), or cocaine (10 mg/kg) plus haloperidol (0.1 mg/kg) …

Cocaine treatments of 2.5, 5.0, 10.0 and 15.0 mg/kg induced dose-dependent increases in
locomotor behavior. This cocaine-induced increase in locomotion was blocked if the animals …

The application of antibodies for immunotherapy was documented as early as 1890 (von
Behring and Kitasato 1890). In the past, polyclonal antibodies found in antiserum against …

This study investigated the effects of prenatal exposure to cocaine on the intracellular
kinetics (ie rate constant of receptor production and degradation) that govern the …

This report investigated whether postnatal exposure to cocaine affects the index of 5-HT2A
receptor function during development by utilizing the ability of the 5-HT2A/C agonist DOI to …

Both humans and experimental animals demonstrate gender differences in response to
cocaine. However, the mechanisms underlying these differences remain unclear. The …

Drug addiction does not result simply from drug exposure, but rather a complex interaction
between the drug, the individual's biological predisposition, and various environmental …