The biochemical and behavioral effects of a nonpeptidic, selective, and brain-penetrant
agonist at the ORL1 receptor are reported herein. This low molecular weight compound {(1 …

Nociceptin and the ORL1 receptor share high sequence similarity with opioid peptides,
particularly dynorphin A, and their receptors. However, nociceptin and dynorphin A may use …

The endogenous ligand for the orphan NOR receptor (earlier named ORL1) was recently
discovered. This ligand, nociceptin/orphanin FQ is involved in a number of pharmacological …

The endogenous ligand for the orphan opioid receptor, orphanin FQ/nociceptin (OFQ), has
recently been characterized. The OFQ peptide sequence contains paired basic amino acids …

This article summarizes our recent finding that the nociceptin system is involved in the
regulation of learning and memory. The nociceptin-knockout mice show greater learning …

The effects of fmol doses of nociceptin/orphanin FQ on scopolamine-induced impairment of
learning and/or memory were examined using spontaneous alternation of Y-maze and step …

Nociceptin (noc), a neuropeptide also known as orphanin FQ, is the endogenous ligand of
the G protein-coupled receptor (GPCR) ORL1 (Opioid Receptor-Like1). Noc …

Anew sequence, which encoded a novel G protein-coupled receptor, was disclosed by two
different groups, using the nucleic acid probes based on the delta opioid receptor, first …

Focuses on the perceived role of OrphaninFQ (OFQ/N), also known as nociceptin, in
behavioral fear responses and vulnerability to stress. Functional neuroanatomy of OFQ/N; …

The intrathecal (it) injection of 3.0 fmol nociceptin (orphanin FQ) elicited scratching, biting
and licking responses in mice. N-terminal fragments of nociceptin, nociceptin (1–7) …