A growing number of neurodegenerative diseases have been found to result from the
expansion of an unstable trinucleotide repeat. Over the past 6 years, researchers have …

Within the closing decade of the twentieth century, 14 neurological disorders were shown to
result from the expansion of unstable trinucleotide repeats, establishing this once unique …

An expansion of polyglutamines in the N terminus of huntingtin causes Huntington's disease
(HD) and results in the accrual of mutant protein in the nucleus and cytoplasm of affected …

Huntington's disease (HD) is a fatal inherited neurodegenerative disorder characterized by
personality changes, motor impairment, and subcortical dementia. HD is one of a number of …

Instability of CAG DNA trinucleotide repeats is the mutational mechanism for several
neurodegenerative diseases resulting in the expansion of a polyglutamine (polyQ) tract …

Huntington's disease (HD), spinocerebellar ataxias types 1 and 3 (SCA1, SCA3), and
spinobulbar muscular atrophy (SBMA) are caused by CAG/polyglutamine expansion …

At least eight inherited neurodegenerative diseases are caused by expanded CAG repeats
encoding polyglutamine (polyQ) stretches. Although cytotoxicities of expanded polyQ …

At least eight dominant human neurodegenerative diseases are due to the expansion of a
polyglutamine within the disease proteins. This confers toxicity on the proteins and is …

Proteolysis via the ubiquitin system plays important roles in a variety of basic cellular
processes. Among these are regulation of cell cycle and division, modulation of the immune …

Abstract Spinocerebellar ataxia type 2 (SCA2) is caused by expansion of a polyglutamine
tract in ataxin-2, a protein of unknown function. Using the yeast two-hybrid system, we …