The maintenance of health depends on the coordinated and tightly regulated expression of
genetic information. Certain forms of leukemia have become paradigms for the pathogenic …

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that
influence transcription by selectively deacetylating or acetylating the e-amino groups of …

Many chemotherapeutic agents induce mitochondrial-membrane disruption to initiate
apoptosis. However, the upstream events leading to drug-induced mitochondrial …

Histone deacetylase (HDACs) regulate histone acetylation by catalyzing the removal of
acetyl groups on the NH2-terminal lysine residues of the core nucleosomal histones …

Histone acetylation has long been associated with transcriptional activation, whereas
conversely, deacetylation of histones is associated with gene silencing and transcriptional …

Histone deacetylase inhibitors (HDACIs) inhibit the growth of a variety of transformed cells in
culture. We demonstrated previously that the hybrid-polar HDACI m-carboxycinnamic acid …

Purpose: We have synthesized a series of hybrid polar compounds that induce
differentiation and/or apoptosis of various transformed cells. These agents are also potent …

Histone deacetylase inhibitors show promise as chemotherapeutic agents and have been
demonstrated to block proliferation in a wide range of tumor cell lines. Much of this …

Histone deacetylase (HDAC) appears to play an important role in the pathogenesis of acute
promyelocytic leukaemia (APL) as it is recruited by both PML–RARα and PLZF/RARα in …

Transformed cells have escaped normal growth regulatory signals and may be blocked at
discrete states of differentiation prior to the stage of terminal cell division and/or apoptosis …