Flies, genes, and learning

S Waddell, WG Quinn - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Flies can learn. For the past 25 years, researchers have isolated mutants,
engineered mutants with transgenes, and tested likely suspect mutants from other screens …

Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)

H Hashimoto, N Shintani, K Tanaka… - Proceedings of the …, 2001 - National Acad Sciences
Pituitary adenylate cyclase-activating polypeptide (PACAP) has been conserved remarkably
during evolution and is widely expressed in the mammalian brain. In Drosophila, mutation of …

Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection

RV Morris, CB Shoemaker, JR David… - The Journal of …, 2001 - journals.aai.org
Bloodfeeding arthropods transmit many of the world's most serious infectious diseases.
Leishmania are transmitted to their mammalian hosts when an infected sandfly probes in the …

Expression of receptor-activity modifying protein (RAMP) mRNAs in the mouse brain

T Ueda, S Ugawa, Y Saishin, S Shimada - Molecular brain research, 2001 - Elsevier
Receptor activity modifying proteins (RAMPs) comprise a family of accessory proteins for G
protein-coupled receptors (GPCRs). They function as receptor modulators that determine the …

Role of neurotransmitters and neuropeptides in the regulation of the adrenal cortex

C Delarue, V Contesse, S Lenglet, F Sicard… - Reviews in Endocrine …, 2001 - Springer
It has long been thought that the functions of the adrenal cortex were mainly if not
exclusively regulated by circulating hormones, ie adrenocorticotropin (ACTH) and …

BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons

D Frechilla, A García-Osta, S Palacios… - …, 2001 - journals.lww.com
In primary cultures from rat cerebral cortex, pituitary adenylate cyclase-activating
polypeptide (PACAP-38) exerted a protective effect on cell death induced by the excitotoxin …

Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor

H Jongsma, LME Pettersson, Y Zhang, MK Reimer… - …, 2001 - journals.lww.com
The neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) has been
proposed to have a role in nociception. Here we have used the formalin test, thermal laser …

Two basic residues of the h-VPAC1 receptor second transmembrane helix are essential for ligand binding and signal transduction

RM Solano, I Langer, J Perret, P Vertongen… - Journal of Biological …, 2001 - ASBMB
We mutated the vasoactive intestinal peptide (VIP) Asp 3 residue and two VPAC 1 receptor
second transmembrane helix basic residues (Arg 188 and Lys 195). VIP had a lower affinity …

Differential effects of PACAP-38 on synaptic responses in rat hippocampal CA1 region

M Roberto, R Scuri, M Brunelli - Learning & Memory, 2001 - learnmem.cshlp.org
Pituitary adenylate cyclase-activating polypeptide (PACAP-38) is a member of the
vasointestinal polypeptide (VIP)/secretin/glucagon family of neuropeptides for which …

Exogenous NT‐3 and NGF differentially modulate PACAP expression in adult sensory neurons, suggesting distinct roles in injury and inflammation

H Jongsma, N Danielsen, JM Johnston… - European Journal of …, 2001 - Wiley Online Library
Expression of pituitary adenylate cyclase‐activating polypeptide in sensory neurons varies
with injury or inflammation. The neurotrophins NGF and NT‐3 are profound regulators of …