The specific interaction between the α/β T cell receptor (TCR) and a peptide-bound major
histocompatibility complex (MHC) molecule triggers the adaptive immune response …

T-cell antigen receptors composed of γ and δ polypeptide chains (γδTCRs) can directly
recognize antigens in the form of intact proteins or non-peptide compounds, unlike αβTCRs …

γδ T lymphocytes in the intestinal intraepithelial layer (γδ IELs) are thought to contribute to
immune competence, but their actual function remains poorly understood. Here we used …

Human γδ T cells display unique repertoires of Ag specificities largely imposed by selective
usages of distinct Vγ and Vδ genes. Among them, Vγ2/Vδ2+ T cells predominate in the …

Although the T cell receptor (TCR)-Á genes [1] were initially considered by some to be no
more than evolutionary flotsam, it soon became clear that cell surface receptors bearing …

γδ T cells are believed to recognize tissue injury caused by infections, tumours, as well as
chemical and physical agents. The present study was carried out to study the feasibility of …

In humans, the majority of mature T lymphocytes are· ß T cells; a small subset of around 1–
5% of lymphocytes in the adult thymus and peripheral blood T cells are Á‰ T cells. Á‰ T …

T cells are a critical component of host immune responses against bacterial pathogens. T
cell activation relies on recognition of antigen (s) derived from the bacteria, and this …

Nature 410, 809-812 (2001). This paper should have included the following
acknowledgement: We thank the US Department of Energy for financial support, with …

Background and Objectives: γδT cell populations are well-known for their unique distribution
(eg intra-epithelial lymphocytes). Though their ligands play a major role in the immune …