ATP acts as a humoral mediator to control cell function extracellularly. The receptors that
mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the …

Receptor subtypes for purines have been identified in a variety of tissues, increasing interest
in the roles of purine-mediated signalling in pathophysiological processes. Growing …

The present study explores the possible involvement of a purinergic mechanism in
mechanosensory transduction in the bladder using P2X3 receptor knock-out (P2X3−/−) and …

ATP is found in every cell, where it is a major source of energy. But in the nervous system,
ATP also has additional actions, which include its role in fast synaptic transmission and …

P2X receptors are a family of ligand-gated ion channels, activated by extracellular ATP. The
seven subunits cloned (P2X1–7) can assemble to form homomeric and heteromeric …

ATP, besides an intracellular energy source, is an agonist when applied to a variety of
different cells including cardiomyocytes. Sources of ATP in the extracellular milieu are …

The potential importance for nociception of P2X receptors, the ionotropic receptors activated
by ATP, is underscored by the variety of pain states in which this endogenous ligand can be …

The ionotropic ATP receptor subunits P2X1–6 receptors play important roles in synaptic
transmission, yet the P2X7receptor has been reported as absent from neurons in the normal …

ATP mediates fast excitatory synaptic transmission in some regions of the central nervous
system through activation of P2X receptors. Nonetheless, the functional significance of ATP …

The control and maintenance of vascular tone is due to a balance between vasoconstrictor
and vasodilator pathways. Vasomotor responses to neural, metabolic and physical factors …