Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

Histamine-releasing neurons are located exclusively in the TM of the hypothalamus, from
where they project to practically all brain regions, with ventral areas (hypothalamus, basal …

In the central nervous system (CNS) of both vertebrates and invertebrates, biogenic amines
are important neuroactive molecules. Physiologically, they can act as neurotransmitters …

Histamine is a multifunctional hormone that regulates smooth muscle contraction in the
airways, acid secretion in the gut, and neurotransmitter release in the central nervous …

We report the discovery, tissue distribution and pharmacological characterization of a novel
receptor, which we have named H4. Like the three histamine receptors reported previously …

Atopic diseases such as allergy and asthma are characterized by increases in Th2 cells and
serum IgE antibodies. The binding of allergens to IgE on mast cells triggers the release of …

The orexins (orexin A and B, also known as hypocretin 1 and 2) are two recently identified
neuropeptides (de Lecea et al., 1998; Sakurai et al., 1998) which are importantly implicated …

We identified the cDNAs of three functional rat H3 receptor isoforms (H3A, H3B, and H3C)
and one nonfunctional truncated H3 receptor (H3T). The H3A, H3B, and H3C receptor …

Whether the job is waking the brain after a peaceful sleep, initiating gastric secretion when
dinner is served or orchestrating the elements of inflammation after a mosquito bite …

We report the characterization by genomics-based approach of the human H4-receptor
gene structure. The H4-receptor gene have been mapped by radiation hybrid experiments …