Itraconazole is a triazole antifungal agent that has a broad spectrum of activity and is well
tolerated. Itraconazole is highly efficacious, particularly because its main metabolite, hydroxy …

Itraconazole is a triazole antifungal agent with a broad spectrum of activity. It is well tolerated
and highly efficacious, particularly because its main metabolite, hydroxy‐itraconazole, also …

Background: Amphotericin B deoxycholate is currently the standard empirical antifungal
therapy in neutropenic patients with cancer who have persistent fever that does not respond …

The incidence of invasive fungal infection has increased in recent years. Most infections are
caused by Candida albicans and Aspergillus spp. but the emergence of other fungal …

Aims Itraconazole is a potent inhibitor of CYP3A4 activity and is often used in combination
with corticosteroids. Since the latter are partly metabolized by CYP3A4, we studied the …

The management of superficial fungal infections differs significantly from the management of
systemic fungal infections. Most superficial infections are treated with topical antifungal …

The broad spectrum antifungal itraconazole is an effective and well tolerated agent for the
prophylaxis and treatment of systemic fungal infections. The recent development of an …

We investigated the pharmacokinetics and safety of an oral solution of itraconazole in two
groups of neutropenic children stratified by age. Effective concentrations of itraconazole in …

In the standard treatment of patients with haematological malignancy, immunosuppressive
therapy produces prolonged periods of neutropenia and mucositis, which increase the risk …

Invasive fungal infections remain a common cause of morbidity and mortality among patients
with leukemia who become further compromised by neutropenia. Candida and Aspergillus …