Potassium channels, a group of specialized membrane proteins, enable K+ ions to flow
selectively across cell membranes. Transmembrane K+ currents underlie electrical …

OBJECTIVES We sought to study the role of IKAChin atrial fibrillation (AF) and the potential
electrophysiologic effects of a specific IKAChantagonist. BACKGROUND IKAChmediates …

We have isolated from a human genomic library the human 5-hydroxytryptamine 5-HT5A
and 5-HT5B genes. The human 5-HT5A gene encodes a protein with similar characteristics …

1 The rectification property of the inward rectifier K+ channel is chiefly due to the block of
outward current by cytoplasmic Mg2+ and polyamines. In the cloned inward rectifier K+ …

G protein–coupled inwardly rectifying potassium channels, GIRK/Kir3. x, are gated by the
Gβγ subunits of the G protein. The molecular mechanism of gating was investigated by …

Protein kinase A (PKA) is targeted to discrete subcellular locations close to its intended
substrates through interaction with Akinase-anchoringproteins (AKAPs). Ion channels …

1 Members of the Kir3. 0 family of inwardly rectifying K+ channels are expressed in
neuronal, atrial and endocrine tissues and play key roles in generating late inhibitory …

This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors,
purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding …

G protein-coupled inward rectifier K+ channels (GIRK channels) are activated directly by the
G protein βγ subunit. The crystal structure of the G protein βγ subunits reveals that the β …

Regulators of G protein signaling RGS4 and RGS7 accelerate the kinetics of K+ channels
(GIRKs) in the Xenopus oocyte system. Here, via quantitative analysis of RGS expression …