A new mathematical model for avascular tumour growth

JA Sherratt, MAJ Chaplain - Journal of mathematical biology, 2001 - Springer
The early development of solid tumours has been extensively studied, both experimentally
via the multicellular spheroid assay, and theoretically using mathematical modelling. The …

The migration of cells in multicell tumor spheroids

GJ Pettet, CP Please, MJ Tindall… - Bulletin of mathematical …, 2001 - Elsevier
A mathematical model is proposed to explain the observed internalization of microspheres
and3H-thymidine labelled cells in steady-state multicellular spheroids. The model uses the …

Impact of proliferative activity and tumorigenic conversion on mitochondrial function of fibroblasts in 2D and 3D culture

LA Kunz-Schughart, RC Habbersett, JP Freyer - Cell biology international, 2001 - Elsevier
The purpose of the present study was to examine mitochondrial function in differently
transformed cells relative to their tumorigenic state and proliferative activity in vitro. An …