Nuclear magnetic resonance spectroscopy and imaging in animal research
JC Chatham, SJ Blackband - IlAR Journal, 2001 - academic.oup.com
Nuclear magnetic resonance (NMR) spectroscopy and imaging can be used to investigate,
noninvasively, a wide range of biological processes in systems as diverse as protein …
noninvasively, a wide range of biological processes in systems as diverse as protein …
pH and chemotherapy
N Raghunand, RJ Gillies - The Tumour Microenvironment …, 2001 - Wiley Online Library
In vivo pH measurements by magnetic resonance spectroscopy reveal the presence of large
regions of acidic extracellular pH in tumours, with the intracellular pH being maintained in …
regions of acidic extracellular pH in tumours, with the intracellular pH being maintained in …
Mapping Extracellular pH in Rat Brain Gliomas in Vivo by H Magnetic Resonance Spectroscopic Imaging: Comparison with Maps of Metabolites
ML García-Martín, G Hérigault, C Rémy, R Farion… - Cancer research, 2001 - AACR
The value of extracellular pH (pHe) in tumors is an important factor in prognosisand choice
of therapy. We demonstrate here that pHe can be mapped in vivo in a rat brain glioma by 1H …
of therapy. We demonstrate here that pHe can be mapped in vivo in a rat brain glioma by 1H …
Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone
N Raghunand, B Mahoney, R van Sluis, B Baggett… - Neoplasia, 2001 - Elsevier
Uptake of weak acid and weak base chemotherapeutic drugs by tumors is greatly influenced
by the tumor extracellular/interstitial pH (pH e), the intracellular pH (pH i) maintained by the …
by the tumor extracellular/interstitial pH (pH e), the intracellular pH (pH i) maintained by the …
Scanning electrochemical microscopy of living cells: Part 2. Imaging redox and acid/basic reactivities
B Liu, W Cheng, SA Rotenberg, MV Mirkin - Journal of Electroanalytical …, 2001 - Elsevier
Amperometric feedback and potentiometric modes of the scanning electrochemical
microscope (SECM) have been used to image the topography and map redox and acid …
microscope (SECM) have been used to image the topography and map redox and acid …
pH-sensitive paramagnetic liposomes as MRI contrast agents: in vitro feasibility studies
KE Løkling, SL Fossheim, R Skurtveit… - Magnetic resonance …, 2001 - Elsevier
A novel type of pH-sensitive paramagnetic contrast agent is introduced; a low molecular
weight gadolinium (Gd) chelate (GdDTPA-BMA) encapsulated within pH-sensitive …
weight gadolinium (Gd) chelate (GdDTPA-BMA) encapsulated within pH-sensitive …