The endocannabinoid nervous system: unique opportunities for therapeutic intervention

AC Porter, CC Felder - Pharmacology & therapeutics, 2001 - Elsevier
The active principle in marijuana, Δ9-tetrahydrocannabinol (THC), has been shown to have
wide therapeutic application for a number of important medical conditions, including pain …

Endogenous cannabinoid as a retrograde messenger from depolarized postsynaptic neurons to presynaptic terminals

T Maejima, T Ohno-Shosaku, M Kano - Neuroscience research, 2001 - Elsevier
Cannabinoid receptors are the molecular targets for the active component Δ9-
tetrahydrocannabinol of marijuana and hashish, and constitute a major family of G protein …

Studies on [3H] CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with …

B Dean, S Sundram, R Bradbury, E Scarr, D Copolov - Neuroscience, 2001 - Elsevier
A number of studies suggested that cannabis use can cause or exacerbate psychoses and
may increase the risk of developing schizophrenia. These findings suggest that changes in …

Evidence for a new G protein-coupled cannabinoid receptor in mouse brain

CS Breivogel, G Griffin, V Di Marzo, BR Martin - Molecular pharmacology, 2001 - ASPET
The purpose of these studies was to support the hypothesis that an undiscovered
cannabinoid receptor exists in brain.[35S] GTPγS binding was stimulated by anandamide …

Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects

MJ Wallace, JL Wiley, BR Martin… - European journal of …, 2001 - Elsevier
The cannabinoid CB1 receptor has been shown to be the primary site of action for
cannabinoid-induced effects on the central nervous system. Activation of this receptor has …

[HTML][HTML] Direct inhibition of T‐type calcium channels by the endogenous cannabinoid anandamide

J Chemin, A Monteil, E Perez‐Reyes, J Nargeot… - The EMBO …, 2001 - embopress.org
Low‐voltage‐activated or T‐type Ca 2+ channels (T‐channels) are widely expressed,
especially in the central nervous system where they contribute to pacemaker activities and …

In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor

H Iwamura, H Suzuki, Y Ueda, T Kaya, T Inaba - Journal of Pharmacology …, 2001 - ASPET
JTE-907 [N-(benzo [1, 3] dioxol-5-ylmethyl)-7-methoxy-2-oxo-8-pentyloxy-1, 2-
dihydroquinoline-3-carboxamide] was evaluated in vitro and in vivo as a novel selective …

Sex differences in antinociceptive and motoric effects of cannabinoids

AH Tseng, RM Craft - European journal of pharmacology, 2001 - Elsevier
Cannabinoids are currently used for the treatment of excessive weight loss and nausea;
however, there are very few studies that have examined cannabinoid effects in females of …

Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord

V Morisset, L Urban - Journal of neurophysiology, 2001 - journals.physiology.org
The effect of cannabinoids on excitatory transmission in the substantia gelatinosa was
investigated using intracellular recording from visually identified neurons in a transverse …

[HTML][HTML] Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries

R White, WSV Ho, FE Bottrill, WR Ford… - British journal of …, 2001 - ncbi.nlm.nih.gov
Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries - PMC
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