At the level of the spinal cord, pathological pain is classically viewed as being created and
maintained solely by neurons. Glia (microglia and astrocytes) were not considered to play a …

We have recently developed a model of sciatic inflammatory neuritis (SIN) to assess how
immune activation near peripheral nerves influences somatosensory processing …

The cytokine tumor necrosis factorα (TNFα) and the hormone insulin-like growth factor-I (IGF-
I) have both been shown to regulate inflammatory events in the central nervous system …

Microglia respond to any disturbance in the CNS which poses a threat to physiological
homeostasis. Although these responses are secondary, mainly to neuronal alterations, the …

Pain is an everyday occurrence for humans and other animals, helping to protect against
injury, but for some it is also a continuous relentless crippling sensory experience that …