Biodegradable polymeric scaffolds for musculoskeletal tissue engineering

CM Agrawal, RB Ray - … Research: An Official Journal of The …, 2001 - Wiley Online Library
Biodegradable scaffolds have played an important role in a number of tissue engineering
attempts over the past decade. The goal of this review article is to provide a brief overview of …

Current trends in the enhancement of fracture healing

D Hannouche, H Petite, L Sedel - The Journal of Bone & Joint …, 2001 - boneandjoint.org.uk
Repair of fractures involves a sequence of dynamic events which ultimately restores the
integrity of the bone and its biomechanical properties. 1 In some cases healing is …

Engineering new bone tissue in vitro on highly porous poly(α‐hydroxyl acids)/hydroxyapatite composite scaffolds

PX Ma, R Zhang, G Xiao… - Journal of Biomedical …, 2001 - Wiley Online Library
Engineering new bone tissue with cells and a synthetic extracellular matrix (scaffolding)
represents a new approach for the regeneration of mineralized tissues compared with the …

Biodegradable polymer/hydroxyapatite composites: surface analysis and initial attachment of human osteoblasts

SC Rizzi, DJ Heath, AGA Coombes… - … Research: An Official …, 2001 - Wiley Online Library
Biodegradable polymer/hydroxyapatite (HA) composites have potential application as bone
graft substitutes. Thin films of polymer/HA composites were produced, and the initial …

Hydrophilic poly (DL-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells

E Walter, D Dreher, M Kok, L Thiele, SG Kiama… - Journal of Controlled …, 2001 - Elsevier
Biodegradable poly (lactide-co-glycolide)(PLGA) microspheres have a proven track record
for drug delivery and are suggested to be ideal carrier systems to target therapeutics into …

Biocompatibility testing of novel starch-based materials with potential application in orthopaedic surgery: a preliminary study

SC Mendes, RL Reis, YP Bovell, AM Cunha… - Biomaterials, 2001 - Elsevier
This paper describes an extensive biocompatibility evaluation of biodegradable starch-
based materials aimed at orthopaedic applications as temporary bone replacement/fixation …

Myotoxicity studies of injectable biodegradable in-situ forming drug delivery systems

H Kranz, GA Brazeau, J Napaporn, RL Martin… - International journal of …, 2001 - Elsevier
The objective of the study was to investigate the potential in-vitro and in-vivo myotoxicity of
different in-situ forming biodegradable drug delivery systems, namely in-situ Microparticle …

Basic science of articular cartilage repair

KA Athanasiou, AR Shah, RJ Hernandez… - Clinics in sports …, 2001 - Elsevier
Although highly desirable, functional restoration of diseased and damaged human articular
cartilage continues to remain one of the most challenging orthopaedic problems. The clinical …

Effect of RGD coating on osteocompatibility of PLGA‐polymer disks in a rat tibial wound

K Eid, E Chen, L Griffith… - Journal of Biomedical …, 2001 - Wiley Online Library
Osteocompatibility of porous polylactic‐glycolic acid (PLGA) disks coated with synthetic
peptides was assessed in 5‐mm diameter unicortical tibial osseous wounds in rats. The …

Study of a (trimethylenecarbonate-co-ε-caprolactone) polymer—Part 2: in vitro cytocompatibility analysis and in vivo ED1 cell response of a new nerve guide

T Fabre, M Schappacher, R Bareille, B Dupuy, A Soum… - Biomaterials, 2001 - Elsevier
Future surgical strategies to restore neurological function in peripheral nerve loss may
involve replacement of nerve tissue with cultured Schwann cells using biodegradable …