The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

Oncolytic herpes simplex virus type 1 (HSV-1) vectors are promising therapeutic agents for
cancer. Their efficacy depends on the extent of both intratumoral viral replication and …

Herpes simplex virus type 1 (HSV-1) is a prevalent microbial pathogen infecting 60% to 90%
of the adult world population. The co-evolution of the virus with humans is due, in part, to …

Kaposi's sarcoma-associated herpesvirus encodes two transmembrane proteins (modulator
of immune recognition [MIR] 1 and MIR2) that downregulate cell surface molecules (MHC-I …

Virus infection induces an antiviral response that is predominantly associated with the
synthesis and secretion of soluble interferon. Here, we report that herpes simplex virus type …

Herpes simplex viruses (HSV) have developed several immunoevasive strategies. Here we
demonstrate a novel mechanism by which HSV type 1 may interfere with the immune …

Here we present the first complete genomic sequence of Marek's disease virus serotype 3
(MDV3), also known as turkey herpesvirus (HVT). The 159,160-bp genome encodes an …

We sought to examine the effects of varicella-zoster virus (VZV) infection on the expression
of major histocompatibility complex class I (MHC I) molecules by human fibroblasts and T …

Replication-competent, attenuated herpes simplex viruses (HSV) have been demonstrated
to be effective oncolytic agents in a variety of malignant tumors. Cytokine gene transfer has …

Herpes simplex virus (HSV) has several potential advantages as a vector for delivering
genes to the nervous system. The virus naturally infects and remains latent in neurons and …