Trk receptor tyrosine kinases: a bridge between cancer and neural development
A Nakagawara - Cancer letters, 2001 - Elsevier
The proto-oncogene Trks encode the high-affinity receptor tyrosine kinases for
neurotrophins of a nerve growth factor (NGF) family. The Trk signals spatiotemporally …
neurotrophins of a nerve growth factor (NGF) family. The Trk signals spatiotemporally …
Assessing TP53 status in human tumours to evaluate clinical outcome
TP53 is probably the most extensively studied tumour-suppressor gene, and patients with
TP53 mutations are known to have a poor outcome. However, inconsistencies in the …
TP53 mutations are known to have a poor outcome. However, inconsistencies in the …
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX
AFX belongs to a subfamily of Forkhead transcription factors that are phosphorylated by
protein kinase B (PKB), also known as Akt. Phosphorylation inhibits the transcriptional …
protein kinase B (PKB), also known as Akt. Phosphorylation inhibits the transcriptional …
Regulation of p53 localization
SH Liang, MF Clarke - European journal of biochemistry, 2001 - Wiley Online Library
Despite intensive study of p53, the regulation of p53 cellular localization is still poorly
understood. This is an overview of the elements and molecules involved in p53 …
understood. This is an overview of the elements and molecules involved in p53 …
p53 cellular localization and function in neuroblastoma: evidence for defective G1 arrest despite WAF1 induction in MYCN-amplified cells
DA Tweddle, AJ Malcolm, M Cole, ADJ Pearson… - The American journal of …, 2001 - Elsevier
This study investigated the hypothesis that p53 accumulation in neuroblastoma, in the
absence of mutation, is associated with functional inactivation, which interferes with …
absence of mutation, is associated with functional inactivation, which interferes with …
p53, p63 and p73–solos, alliances and feuds among family members
UM Moll, S Erster, A Zaika - Biochimica et Biophysica Acta (BBA)-Reviews …, 2001 - Elsevier
p53 controls crucial stress responses that play a major role in preventing malignant
transformation. Hence, inactivation of p53 is the single most common genetic defect in …
transformation. Hence, inactivation of p53 is the single most common genetic defect in …
Activation of p53 by roscovitine-mediated suppression of MDM2 expression
W Lu, L Chen, Y Peng, J Chen - Oncogene, 2001 - nature.com
The p53 tumor suppressor is regulated by the MDM2 oncoprotein. Overexpression of MDM2
maintains p53 at low levels and contributes to the functional inactivation of p53 in a subset of …
maintains p53 at low levels and contributes to the functional inactivation of p53 in a subset of …
A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135)
S Akakura, M Yoshida, Y Yoneda… - Journal of Biological …, 2001 - ASBMB
Mouse temperature-sensitive p53 Val-135 accumulates in the nucleus and acts as a" wild-
type" at 32° C while it is sequestered in the cytoplasm at 37° C. The cytoplasmic p53 Val-135 …
type" at 32° C while it is sequestered in the cytoplasm at 37° C. The cytoplasmic p53 Val-135 …
Autoimmunity to the p53 protein is a feature of systemic lupus erythematosus (SLE) related to anti-DNA antibodies
J Herkel, A Mimran, N Erez, N Kam, AW Lohse… - Journal of …, 2001 - Elsevier
The induction of anti-DNA autoantibodies in systemic lupus erythematosus (SLE) patients is
problematic because mammalian DNA is poorly immunogenic at best. Here we demonstrate …
problematic because mammalian DNA is poorly immunogenic at best. Here we demonstrate …
p53: an overview of over two decades of study.
p53 is the most commonly mutated gene in human cancers. It encodes a 53 kilodalton
protein with several evolutionarily conserved domains viz sequence-specific DNA binding …
protein with several evolutionarily conserved domains viz sequence-specific DNA binding …