Spreading depression (SD), a transient reversible phenomenon with characteristic ionic,
metabolic and hemodynamic changes, has been known for over 55 years. A vast number of …

In intracranial structures unmyelinated C-and Aδ-fibers of the trigeminal nerve transmit pain
stimuli from meninges to the trigeminal nucleus caudalis (Sp5C). Peripheral nerve endings …

1 The mammalian brain ventricles are lined with ciliated ependymal cells. As yet little is
known about the mechanisms by which neurotransmitters regulate cilia beat frequency …

BACKGROUND—Migraine results from episodic changes in central nervous system
physiologic function in hyperexcitable brain manifested by abnormal energy metabolism …

Although migraine is more common among women than men, the only two large,
randomized trials of low-dose aspirin for migraine prophylaxis have been conducted in men …

Little is known about serotonin (5‐HT) receptors present on brain microvessels that are
innervated by brainstem serotonergic neurons. Using 5‐HT, sumatriptan and subtype …

5-Hydroxytryptamine1B (5-HT1B) receptors have been implicated in mediating arterial
contraction to 5-HT. Additionally, the 5-HT1B receptor has been reported to be “unmasked” …

Extracts of Australian plants were screened to detect constituents affecting adenosine di-
phosphate (ADP) induced platelet aggregation and [14C] 5-hydroxytryptamine (5-HT) …

The novel antimigraineur, dotarizine, inhibited 5-HT (5 hydroxytryptamine)-evoked
contractions of rabbit vertebral, aorta, femoral and mesenteric arteries, with IC50s of 1.35 …

Platelet 3H ketanserin binding was studied in 33 patients of migraine and 30 healthy
controls. The binding characteristics: equilibrium dissociation constant (Kd) and maximal …