Phosphatidylcholine species are about 70% of the lipid in surfactant, and
dipalmitoylphosphatidylcholine (DPPC) is about 60% of the phosphatidylcholine species …

Genetic risk for respiratory distress in infancy has been recognized with increasing
frequency in neonatal intensive care units. Reports of family clusters of affected infants and …

The surfactant protein C (SP-C) gene encodes an extremely hydrophobic, 4-kDa peptide
produced by alveolar epithelial cells in the lung. To discern the role of SP-C in lung function …

Pulmonary surfactant is an amalgam of proteins and phospholipids which serves to maintain
a low surface tension within the alveolar regions of the lungs during changes in lung …

A dansylated form of porcine surfactant-associated protein C (Dns-SP-C), bearing a single
dansyl group at its N-terminal end, has been used to characterize the lipid–protein and …

Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in
the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant …

Respiratory distress syndrome (RDS) is a disease characterized by neonatal respiratory
failure. It is principally caused by a deficiency of pulmonary surfactant, which is a lipoprotein …

Molecular biology is increasingly affecting all areas of clinical medicine, including pediatric
critical care medicine. Recent advances in genomics will allow for a more in-depth …

Genetic diversity exerts profound effects on variation in human drug response in adults, but
comparatively little research that specifically relates to genetically abnormal responses in …

Mammalian pulmonary surfactants contain four distinct surfactant proteins, termed surfactant
proteins A, B, C, and D (SP-A, SP-B, SP-C, and SP-D), that play unique roles in host …