The T cell compartment of adaptive immunity provides vertebrates with the potential to
survey for and respond specifically to an incredible diversity of antigens. The T cell …

Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-
cell receptor complex after antigen recognition, and one provided on engagement of co …

Abstract Programmed death 1 (PD-1)–deficient mice develop a variety of autoimmune-like
diseases, which suggests that this immunoinhibitory receptor plays an important role in …

Scurfy (sf) is an X-linked recessive mouse mutant resulting in lethality in hemizygous males
16–25 days after birth, and is characterized by overproliferation of CD4+ CD8–T …

Recent advances in the understanding of T cell activation have led to new therapeutic
approaches in the treatment of immunological disorders. One attractive target of intervention …

PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the
PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The …

We have recently identified and clonedFoxp3, the gene defective in mice with thescurfy
mutation. The immune dysregulation documented in these mice and in humans with …

The requirement for CTLA-4 during the induction of peripheral T cell tolerance in vivo was
investigated using naive TCR transgenic T cells lacking CTLA-4. CTLA-4−/− T cells are …

Tissue inhibitors of metalloproteinases regulate ECM degradation by matrix
metalloproteinases (MMPs). We have developed a mouse line deficient for tissue inhibitor of …

Because mutations in Rab27a have been linked to immune defects in humans, we have
examined cytotoxic lymphocyte function in ashen mice, which contain a splicing mutation in …