Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits
MP Mattson, SL Chan - Journal of Molecular Neuroscience, 2001 - Springer
Calcium is one of the most important intracellular messengers in the brain, being essential
for neuronal development, synaptic transmission and plasticity, and the regulation of various …
for neuronal development, synaptic transmission and plasticity, and the regulation of various …
Presenilin mutations and calcium signaling defects in the nervous and immune systems
MP Mattson, SL Chan, S Camandola - Bioessays, 2001 - Wiley Online Library
Abstract Presenilin‐1 (PS1) is thought to regulate cell differentiation and survival by
modulating the Notch signaling pathway. Mutations in PS1 have been shown to cause early …
modulating the Notch signaling pathway. Mutations in PS1 have been shown to cause early …
Telomerase protects developing neurons against DNA damage-induced cell death
C Lu, W Fu, MP Mattson - Developmental Brain Research, 2001 - Elsevier
In mitotic cells, telomerase adds repeats of a DNA sequence (TTAGGG) to the ends of
chromosomes (telomeres) thereby maintaining their length and preventing cellular …
chromosomes (telomeres) thereby maintaining their length and preventing cellular …
Caspase-mediated suppression of glutamate (AMPA) receptor channel activity in hippocampal neurons in response to DNA damage promotes apoptosis and prevents …
C Lu, W Fu, MP Mattson - Neurobiology of Disease, 2001 - Elsevier
DNA damage in neurons is implicated in the pathogenesis of several neurodegenerative
disorders and may also contribute to the often severe neurological complications in cancer …
disorders and may also contribute to the often severe neurological complications in cancer …
Cyclin-dependent kinases and stroke
DS Park, F Wang, MJ O'Hare - Expert Opinion on Therapeutic …, 2001 - Taylor & Francis
Cyclin-dependent kinases (CDKs) are a group of enzymes predominately known for their
role in cell cycle regulation in proliferating cell types. Increasing evidence, however …
role in cell cycle regulation in proliferating cell types. Increasing evidence, however …
[图书][B] Sublethal hepatic pathology and evidence of intranuclear effects of the cyanobacterial toxin microcystin-LR
RE Guzman - 2001 - search.proquest.com
Microcystin-LR (MCLR) is a hepatotoxin and phosphatase inhibitor produced by Microcystis
aeruginosa. The pathology of sublethal exposure is not well characterized. MCLR …
aeruginosa. The pathology of sublethal exposure is not well characterized. MCLR …