Background: The Canadian Psychiatric Association and the Canadian Network for Mood
and Anxiety Treatments partnered to produce clinical guidelines for psychiatrists for the …

BackgroundTricyclic antidepressants have similar efficacy and slightly lower tolerability than
selective serotonin reuptake inhibitors (SSRIs). However, there are no systematic reviews …

OBJECTIVE: Serotonin selective reuptake inhibitors (SSRIs) are now considered the first-
line pharmacotherapy for panic disorder. The preferential use and the presumption of …

Venlafaxine inhibits presynaptic reuptake of serotonin (5-hydroxytryptamine; 5-HT) and
noradrenaline (norepinephrine). Venlafaxine extended-release (XR) has been investigated …

Noncompliance with prescribed drug regimens is a widespread phenomenon which results
in decreased efficacy and is often associated with increased medical expenditures. Despite …

BackgroundAlthough the efficacy of antidepressants has been demonstrated in randomised,
controlled clinical trials, it is how an antidepressant is used in clinical practice that …

Recent advances in our understanding of both short-and long-term therapeutic interventions
for depressive disorders have necessitated greater precision in defining appropriate …

This meta-analysis examined efficacy and tolerability data from 39 randomized, double-
blind, parallel-group studies comparing paroxetine (n= 1924) with clomipramine (n= 141) or …

Because depressive illness is so prevalent, the majority of patients are managed in primary
care, without recourse to specialist services. Primary care management is seen to fall short …

Background: Although prison inmates are reported to exhibit elevated rates of depressive
disorders, little is known about anti-depressant prescribing patterns in correctional …