Potent antiretroviral therapy initiates normalization of hypergammaglobulinemia and a decline in HIV type 1-specific antibody responses

DW Notermans, JJ De Jong, J Goudsmit… - AIDS research and …, 2001 - liebertpub.com
Next to a profound T cell immunodeficiency, HIV-1 infection induces activation and
dysfunction of B cells, resulting in hypergammaglobulinemia. Whereas T cell immune …

Engineering regulable escherichia coliβ-galactosidases as biosensors for anti-HIV antibody detection in human sera

N Ferrer-Miralles, JX Feliu, S Vandevuer… - Journal of Biological …, 2001 - ASBMB
The activity of engineered, peptide-displaying enzymes is modulated by binding to specific
anti-peptide antibodies. This new concept of a quantitative antibody detection system allows …