The advance in our understanding of the biogenesis of various endogenous opioid
peptides, their anatomical distribution, and the characteristics of the multiple receptors with …

Spinal administration of the endogenous μ-opioid agonist peptide, endomorphin-1, results in
antinociception in rodents, but there are few data about its interaction with other …

Two highly selective μ-opioid receptor agonists, endomorphin-1 and endomorphin-2, have
been identified and postulated to be endogenous ligands for μ-opioid receptors. Intrathecal …

Abstract Endomorphin (EM)-1 and EM-2 are opioid tetrapeptides recently located in the
central nervous system and immune tissues with high selectivity and affinity for the µ-opioid …

DALDA (H-Tyr-d-Arg-Phe-Lys-NH2) and [Dmt1] DALDA (H-Dmt-d-Arg-Phe-Lys-NH2)(Dmt=
2′, 6′-dimethyltyrosine) are potent and highly selective μ-opioid agonists (K i δ/K i μ> …

We have previously demonstrated that the antinociception induced by either endomorphin-1
or endomorphin-2 given supraspinally is mediated by the stimulation of μ-opioid receptors …

We investigated the actions of the endogenous opioid tetra‐peptide endomorphin 1, a
selective μ‐opioid receptor agonist, on oxytocin and vasopressin cell activity in vivo and in …

Nerve injury often leads to chronic, sometimes excruciating, pain. The mechanisms
contributing to this syndrome include neurochemical plasticity in neurons involved in the …

The effects of intracerebroventricular administration of endomorphin-1 and endomorphin-2,
endogenous μ-opioid receptor agonists, on passive avoidance learning associated with …

Development of tolerance in mice pretreated intracerebroventricularly with μ-opioid receptor
agonist endomorphin-1, endomorphin-2, or [d-Ala2, N-Me-Phe4, Gly-ol5]-enkephalin …