Acetylcholine (ACh), the major parasympathetic neurotransmitter, is released by
intrapancreatic nerve endings during the preabsorptive and absorptive phases of feeding. In …

Phosphatidylinositol-4, 5-bisphosphate (PIP2), the precursor of several signaling molecules
in eukayotic cells, is itself also used by cells to signal to membrane-associated proteins …

The Na+-Ca2+ exchanger (NCX) is one of the essential regulators of Ca2+ homeostasis in
cardiomyocytes and thus an important modulator of the cardiac contractile function. The …

Insulin secretion from pancreatic islet β-cells is a tightly regulated process, under the close
control of blood glucose concentrations, and several hormones and neurotransmitters …

ATP sensitive potassium (K-ATP) channels are widely expressed in many cell types
including neurons. K-ATP channels are heteromeric membrane proteins that consist of two …

Investigation of potassium channel biology continues to be an ever-expanding field of
research. The ability of K+ channels to regulate membrane potential accords them a central …

Autonomic stimulation controls heart rate and myocardial excitability and may underlie the
precipitation of both acquired and hereditary arrhythmias. Changes in phosphatidyl inositol …

Insulin is known to regulate pancreatic β-cell function through the activation of cell surface
insulin receptors, phosphorylation of insulin receptor substrate (IRS)-1 and-2, and activation …

Inwardly rectifying potassium channels require binding of phosphatidylinositol‐4, 5‐
bisphosphate (PIP2) for channel activity. Three independent sites (aa 175–206, aa 207 …

ATP-sensitive K (KATP) channels are inhibited by cytosolic ATP, a defining property that
implicitly links these channels to cellular metabolism. Here we report a direct link between …