Chemical inhibitors of protein kinases
AJ Bridges - Chemical reviews, 2001 - ACS Publications
Many excellent and up to date reviews on kinase inhibitors exist, and this area certainly
does not meet the normal criteria for a Chemical Reviews article. However, most of these …
does not meet the normal criteria for a Chemical Reviews article. However, most of these …
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase
Z Lu, G Jiang, P Blume-Jensen… - Molecular and cellular …, 2001 - Am Soc Microbiol
Upregulated epidermal growth factor (EGF) receptor (EGFR) expression and EGFR-induced
signaling have been correlated with progression to invasion and metastasis in a wide variety …
signaling have been correlated with progression to invasion and metastasis in a wide variety …
Phosphorylation cascades control the actions of ethanol on cell cAMP signalling
B Tabakoff, E Nelson, M Yoshimura… - Journal of biomedical …, 2001 - karger.com
Our studies indicate that, in the presence of particular isoforms of adenylyl cyclase (ie, type 7
AC), moderately intoxicating concentrations of ethanol will significantly potentiate transmitter …
AC), moderately intoxicating concentrations of ethanol will significantly potentiate transmitter …
Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide …
M Shindo, K Irie, A Nakahara, H Ohigashi… - Bioorganic & medicinal …, 2001 - Elsevier
Conventional and novel protein kinase C (PKC) isozymes contain two cysteine-rich C1
domains (C1A and C1B), both of which are candidate phorbol-12, 13-dibutyrate (PDBu) …
domains (C1A and C1B), both of which are candidate phorbol-12, 13-dibutyrate (PDBu) …
Protein kinase C-mediated inhibition of μ-opioid receptor internalization and its involvement in the development of acute tolerance to peripheral μ-agonist analgesia
H Ueda, M Inoue, T Matsumoto - Journal of Neuroscience, 2001 - Soc Neuroscience
We investigated the role of protein kinase C (PKC) in cell μ-opioid receptor (MOR)
internalization and MOR-mediated acute tolerance in vivo. When Chinese hamster ovary …
internalization and MOR-mediated acute tolerance in vivo. When Chinese hamster ovary …
Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder: relation to degree of malignancy
L Langzam, R Koren, R Gal, V Kugel… - American journal of …, 2001 - academic.oup.com
We determined the pattern of protein kinase C (PKC) isoform expression in human cell lines
by Western blotting and immunofluorescent staining techniques. In addition, we examined …
by Western blotting and immunofluorescent staining techniques. In addition, we examined …
Modulation of PKCδ tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases
C Benes, SP Soltoff - American Journal of Physiology-Cell …, 2001 - journals.physiology.org
Protein kinase C (PKC) δ becomes tyrosine phosphorylated in rat parotid acinar cells
exposed to muscarinic and substance P receptor agonists, which initiate fluid secretion in …
exposed to muscarinic and substance P receptor agonists, which initiate fluid secretion in …
Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2
Phospholipase D (PLD) activity is elevated in response to most mitogenic signals. Two
mammalian PLD genes (PLD1 and PLD2) have been cloned and their gene products have …
mammalian PLD genes (PLD1 and PLD2) have been cloned and their gene products have …
PKC-δ inhibits anchorage-dependent and-independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells
SR Cerda, M Bissonnette, B Scaglione–Sewell… - Gastroenterology, 2001 - Elsevier
Background & Aims: Previous studies showed decreased protein kinase C (PKC)-δ
expression in azoxymethane-induced rat and sporadic human colonic tumors. To elucidate …
expression in azoxymethane-induced rat and sporadic human colonic tumors. To elucidate …
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction
The mechanism of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion is
still not well understood even though it is thought to be related to the protein kinase …
still not well understood even though it is thought to be related to the protein kinase …