Cystic fibrosis is a genetic disease that is associated with abnormal sweat electrolytes, sino-
pulmonary disease, exocrine pancreatic insufficiency, and male infertility. Insights into …

During the past two decades, several cell membrane receptors, which preferentially bind
extracellular nucleotides, and their analogs have been identified. These receptors …

Two hypotheses have been proposed recently that offer different views on the role of airway
surface liquid (ASL) in lung defense. The “compositional” hypothesis predicts that ASL …

There is controversy over whether abnormalities in the salt concentration or volume of
airway surface liquid (ASL) initiate cystic fibrosis (CF) airway disease. In vivo studies of CF …

The concentration of salt in the thin layer of fluid at the surface of large airways, the airway-
surface liquid (ASL), is believed to be of central importance in airway physiology and in the …

Fluid and macromolecule secretion by submucosal glands in mammalian airways is
believed to be important in normal airway physiology and in the pathophysiology of cystic …

These studies provide evidence that cystic fibrosis transmembrane conductance regulator
(CFTR) potentiates and accelerates regulatory volume decrease (RVD) following hypotonic …

Much of the pulmonary disease in cystic fibrosis is associated with polymorphonuclear
leukocyte-dominated airway inflammation caused by bacterial infection. Respiratory …

Unmethylated CpG dinucleotide motifs in bacterial DNA, as well as oligodeoxynucleotides
(ODN) containing these motifs, are potent stimuli for many host immunological responses …

The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) has been proposed
to be an epithelial cell receptor for Pseudomonas aeruginosa involved in bacterial …