Abstract Rasagiline (N-propargyl-1-(R)-aminoindan) is a selective, irreversible monoamine
oxidase B (MAO B) inhibitor which has been developed as an anti-Parkinson drug. In …

During the last decade, a systematic effort to develop a pharmacological treatment for
Alzheimer disease (AD) has resulted in drugs being registered for the first time in the US and …

Overproduction of the peptide amyloid β (Aβ) is a critical event in Alzheimer's disease (AD).
Systemic administration of 3 M1-selective muscarinic agonists, AF102B, AF150S and …

We have investigated the acute and chronic effect of metrifonate (MTF) and dichlorvos
(DDVP), respectively the prodrug and active acetylcholinesterase inhibitor, on the secretory …

The alternative routes of cleavage of the amyloid precursor protein (APP) result in the
generation and secretion of both soluble APP and β-amyloid, the latter being the main …

Eptastigmine (heptyl‐physostigmine tartrate) is a carbamate derivative of physostigmine in
which the carbamoylmethyl group in position 5 of the side chain has been substituted with a …

Overproduction of the peptide amyloid β (Aβ) is thought to be a critical pathogenetic event in
Alzheimer's disease (AD). Decreasing Aβ production may therefore slow or halt the …

During the last decade, a systematic effort to develop a pharmacological treatment for
Alzheimer's disease (AD) resulted in three drugs being registered for the first time in the US …

The second edition of Management of Dementia combines a balanced review of the latest
knowledge and research in this area with practical guidance based on the authors' …

In this study, entorhinal cortex lesions and/or medial septal area cholinergic lesions were
used in the rat to mimic some of the principal and earliest affects in Alzheimer's disease …