Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in
several age-related neurodegenerative disorders or animal models thereof, including …

It is becoming increasingly evident that the mitochondrial genome may play a key role in
neurodegenerative diseases. Mitochondrial dysfunction is characteristic of several …

Familial amyloid polyneuropathy (FAP) is a neurodegenerative disorder associated with
extracellular deposition of mutant transthyretin (TTR) amyloid fibrils, particularly in the …

Minocycline, a semisynthetic second-generation tetracycline, was reported to have
neuroprotective effects in models of global and focal cerebral ischemia, the R6/2 mouse …

Neural progenitor cells (NPC) can proliferate, differentiate into neurons or glial cells, or
undergo a form of programmed cell death called apoptosis. Although death of NPC occurs …

Nitric oxide (NO) is a biologically active inorganic molecule produced when the
semiessential amino acid l‐arginine is converted to l‐citrulline and NO via the enzyme nitric …

Considerations of natural selection suggest that life span maximization is not a significant
evolutionary priority. 1 Animals in the wild must survive at least long enough to reproduce in …

A very large body of evidence supports the involvement of oxidative stress in
neurodegenerative pathologies. Therefore, therapies based on administration of antioxidant …

Blood-spinal cord barrier (BSCB) strictly maintains the fluid microenvironment of the spinal
cord within a narrow limit 4, 6. Alteration of the BSCB in several diseases inflicting the cord is …

Alzheimer's disease (AD) affects 3–4 million Americans each year making it the major
neurodegenerative disorder of aging. One of the early events in AD is the accumulation and …