BACKGROUND AND AIMS In this study, we prospectively examined the clinical significance
of the microsatellite instability (MSI) phenotype in sporadic colorectal cancer, and …

Background: Microsatellite instability (MSI) is seen in 10%–15% of sporadic colorectal
cancers mostly in the right colon, but the precursors of cancers with MSI remain unknown …

Serrated adenoma has been proposed to be a distinct entity among colorectal neoplasms.
Progression to frank carcinoma has been suggested in individual cases, but the prevalence …

Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer
predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. It is …

The significance of low-level DNA microsatellite instability (MSI-L) is not well understood. K-
ras mutation is associated with MSI-L colorectal cancer and with the silencing of the DNA …

Morphological and molecular studies are beginning to distinguish separate evolutionary
pathways for colorectal cancer. The serrated pathway encompassing hyperplastic aberrant …

Hyperplastic polyposis is a loosely defined syndrome initially thought not to confer a
clinically important predisposition to colorectal cancer. The aim of the current study was to …

A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as
microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with …

Colorectal carcinoma is uncommon in Egypt, but a high proportion of cases occurs before
age 40 years and in the rectum. We compared the molecular pathology of 59 representative …

Adenomas are the precursors of most colorectal cancers. Hyperplastic polyps have been
linked to the subset of colorectal cancers showing DNA microsatellite instability, but little is …