▪ Abstract SP-B is the only surfactant-associated protein absolutely required for postnatal
lung function and survival. Complete deficiency of SP-B in mice and humans results in …

Genetic risk for respiratory distress in infancy has been recognized with increasing
frequency in neonatal intensive care units. Reports of family clusters of affected infants and …

Pulmonary alveolar proteinosis (PAP) is a disorder that rapidly leads to respiratory failure,
because the alveolar spaces fill with a lipid-rich, proteinaceous material that impedes gas …

Pulmonary surfactant is an amalgam of proteins and phospholipids which serves to maintain
a low surface tension within the alveolar regions of the lungs during changes in lung …

ABSTRACT Surfactant protein B (SP-B) deficiency is a disorder of surfactant function with
complete or transient absence of SP-B in term neonates. SP-B, 1 of 4 described surfactant …

Respiratory distress syndrome (RDS) is a disease characterized by neonatal respiratory
failure. It is principally caused by a deficiency of pulmonary surfactant, which is a lipoprotein …

OBJECTIVE: To determine if high-frequency oscillatory ventilation and neuromuscular
blockade improve oxygenation and chest radiographic appearance more effectively than …

Pulmonary alveolar proteinosis is a rare lung disease characterized by the accumulation of
lipoproteinaceous material within the alveoli. Analysis of the lipoproteinaceous materials …

Pulmonary surfactant, a mixture of phospholipids and surfactant proteins, lines the alveolar
space and functions to reduce surface tension at the air-liquid interface. Alveolar type II …