The isolation of an opioid receptor-related clone soon led to the isolation and
characterization of a new neuropeptide, termed orphanin FQ or nociceptin (OFQ/N). This …

Many peptides and transmitters found within the brain also have peripheral sites of action.
We now demonstrate that the brain releases functionally active neurotransmitters …

Despite ample pharmacological evidence for the existence of multiple μ-, δ-and κ-opioid
receptor subtypes, only three genes encoding μ-(MOR), δ-(DOR) and κ-(KOR) opioid …

Nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are two neuropeptides derived from
the same precursor protein that exhibit opposing effects on spinal neurotransmission and …

Until recently the opioid receptor family was thought to consist of only the μ-, δ-and κ-
receptors. The cloning of opioid receptor like receptor (ORL1) and its endogenous ligand …

Pharmacological and receptor-ligand binding studies of the cloned orphanin FQ (OFQ)
receptor suggest that multiple forms of this receptor may exist. To further characterize the …

A novel receptor, the opioid receptor-like orphan receptor (ORL1), is homologous to, but
distinct from, classical opioid receptors. Although initially developed as an opioid receptor …

Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand for the ORL-1/KOR-3 receptor,
produces a wide variety of behavioral responses. Its precursor protein, prepro-OFQ/N …

The present study investigated the roles of the opioid-receptor-like (ORL1) receptor and its
endogenous ligand nociceptin on nociception in the spinal cord of rats. Intrathecal …

The coupling of opioid receptor‐like (ORL1) receptors to adenylyl cyclase has been
investigated in specific layers of the rat main olfactory bulb. Membranes prepared from the …