Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

Cerebral ischemia is accompanied by a marked inflammatory reaction that is initiated by
ischemia-induced expression of cytokines, adhesion molecules, and other inflammatory …

Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal
ischemia in rodents. We examined whether minocycline reduces excitotoxicity in primary …

Background and Purpose—There is growing evidence of the prognostic importance of C-
reactive protein (CRP) in ischemic stroke. However, the independent value of CRP at …

Glutamate excitotoxicity to a large extent is mediated through activation of the N-methyl-d-
aspartate (NMDA)-gated ion channels in several neurodegenerative diseases and ischemic …

Background and Purpose—The prognostic influences of fibrinogen and C-reactive protein
(CRP) levels and their relations in ischemic stroke have not been well described. The aim of …

Background and Purpose—We tested the hypothesis that there are significant long-term
local vascular changes after ministroke that could form a basis for functional recovery …

Degeneration and death of neurons is the fundamental process responsible for the clinical
manifestations of many different neurological disorders of aging, incuding Alzheimer's …

Cyclooxygenase-2 (COX-2), a prostanoid-synthesizing enzyme that contributes to the
toxicity associated with inflammation, has recently emerged as a promising therapeutic …

Neurogenesis in the adult rat dentate gyrus was studied following focal ischemic insults
produced by middle cerebral artery occlusion (MCAO). Animals were subjected to either 30 …