The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …

Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential
anticancer agents for the treatment of solid and hematological malignancies. In recent years …

Angiogenesis is a complex biological process involving the coordinated modulation of many
genes. Histone deacetylases (HDAC) are a growing family of enzymes that mediate the …

The antitumor efficacy of the synthetic benzamide derivative MS-27-275 (MS-275), an
inhibitor of histone deacetylation [T. Suzuki et al., J. Med. Chem., 42: 3001–3003, 1999], was …

We previously reported that apicidin arrested human cancer cell growth through selective
induction of p21 WAF1/Cip1. In this study, the apoptotic potential of apicidin and its …

A workshop on childhood atypical teratoid/rhabdoid tumors of the central nervous system,
sponsored by the National Cancer Institute and the Pediatric Brain Tumor Foundation of the …

The early stage of chronic myelogenous leukemia (CML) is caused by the tyrosine kinase
Bcr-Abl. Imatinib mesylate (also known as STI-571 and Gleevec), a tyrosine kinase inhibitor …

Purpose: Cantharidin, a natural toxin, is the active substance of mylabris and has antitumor
effects in man. Norcantharidin, the demethylated analogue of cantharidin, has been used in …

This study was performed to determine the effect and action mechanisms of sodium butyrate
(NaB) on the growth of breast cancer cells. Butyrate inhibited the growth of all breast cancer …

Multidrug resistance (MDR) mediated by the ATP‐dependent efflux protein P‐glycoprotein
(P‐gp) is a major obstacle to the successful treatment of many cancers. In addition to …