Histone-deacetylase inhibitors: novel drugs for the treatment of cancer
RW Johnstone - Nature reviews Drug discovery, 2002 - nature.com
The opposing actions of histone acetyltransferases (HATs) and histone deacetylases
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …
(HDACs) allow gene expression to be exquisitely regulated through chromatin remodelling …
Histone deacetylase inhibitors in cancer treatment
DM Vigushin, RC Coombes - Anti-cancer drugs, 2002 - journals.lww.com
Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential
anticancer agents for the treatment of solid and hematological malignancies. In recent years …
anticancer agents for the treatment of solid and hematological malignancies. In recent years …
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
CF Deroanne, K Bonjean, S Servotte, L Devy, A Colige… - Oncogene, 2002 - nature.com
Angiogenesis is a complex biological process involving the coordinated modulation of many
genes. Histone deacetylases (HDAC) are a growing family of enzymes that mediate the …
genes. Histone deacetylases (HDAC) are a growing family of enzymes that mediate the …
MS-27-275, an Inhibitor of Histone Deacetylase, Has Marked in Vitro and in Vivo Antitumor Activity against Pediatric Solid Tumors
The antitumor efficacy of the synthetic benzamide derivative MS-27-275 (MS-275), an
inhibitor of histone deacetylation [T. Suzuki et al., J. Med. Chem., 42: 3001–3003, 1999], was …
inhibitor of histone deacetylation [T. Suzuki et al., J. Med. Chem., 42: 3001–3003, 1999], was …
[HTML][HTML] Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells
We previously reported that apicidin arrested human cancer cell growth through selective
induction of p21 WAF1/Cip1. In this study, the apoptotic potential of apicidin and its …
induction of p21 WAF1/Cip1. In this study, the apoptotic potential of apicidin and its …
The Role of INI1 and the SWI/SNF Complex in the Development of Rhabdoid Tumors: Meeting Summary from the Workshop on Childhood Atypical Teratoid …
JA Biegel, G Kalpana, ES Knudsen, RJ Packer… - 2002 - AACR
A workshop on childhood atypical teratoid/rhabdoid tumors of the central nervous system,
sponsored by the National Cancer Institute and the Pediatric Brain Tumor Foundation of the …
sponsored by the National Cancer Institute and the Pediatric Brain Tumor Foundation of the …
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases
D Wisniewski, CL Lambek, C Liu, A Strife, DR Veach… - Cancer research, 2002 - AACR
The early stage of chronic myelogenous leukemia (CML) is caused by the tyrosine kinase
Bcr-Abl. Imatinib mesylate (also known as STI-571 and Gleevec), a tyrosine kinase inhibitor …
Bcr-Abl. Imatinib mesylate (also known as STI-571 and Gleevec), a tyrosine kinase inhibitor …
Induction of apoptosis by norcantharidin in human colorectal carcinoma cell lines: involvement of the CD95 receptor/ligand
F Peng, YQ Wei, L Tian, L Yang, X Zhao, Y Lu… - Journal of cancer …, 2002 - Springer
Purpose: Cantharidin, a natural toxin, is the active substance of mylabris and has antitumor
effects in man. Norcantharidin, the demethylated analogue of cantharidin, has been used in …
effects in man. Norcantharidin, the demethylated analogue of cantharidin, has been used in …
Sodium butyrate induces P53‐independent, Fas‐mediated apoptosis in MCF‐7 human breast cancer cells
V Chopin, RA Toillon, N Jouy… - British journal of …, 2002 - Wiley Online Library
This study was performed to determine the effect and action mechanisms of sodium butyrate
(NaB) on the growth of breast cancer cells. Butyrate inhibited the growth of all breast cancer …
(NaB) on the growth of breast cancer cells. Butyrate inhibited the growth of all breast cancer …
Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P‐glycoprotein‐expressing cells
AA Ruefli, D Bernhard, KM Tainton… - … journal of cancer, 2002 - Wiley Online Library
Multidrug resistance (MDR) mediated by the ATP‐dependent efflux protein P‐glycoprotein
(P‐gp) is a major obstacle to the successful treatment of many cancers. In addition to …
(P‐gp) is a major obstacle to the successful treatment of many cancers. In addition to …