Aromatase is the cytochrome P450 enzyme responsible for the last step of estrogen
biosynthesis, and aromatase inhibitors constitute an important class of drugs in clinical use …

Ovarian stimulation is applied during infertility management either alone or in conjunction
with intrauterine insemination and assisted reproductive technologies. At the present time …

One third of all breast cancers and two thirds of postmenopausal breast cancers are
estrogen dependent. Antiestrogen strategies, such as inhibition of estrogen-receptor binding …

Estrogens are involved in numerous physiological processes and have crucial roles in
certain disease states, such as mammary carcinomas. Estradiol, the most potent …

To gain insight into the catalytic function of aromatase, we studied aromatization of a series
of 6α-and 6β-ether-substituted (methoxy, ethoxy, and n-butoxy) androst-4-ene-3, 17-dione …

4b, 19-Dihydroxyandrost-5-en-17-one (6) is an excellent competitive inhibitor of estrogen
synthetase (aromatase). Alternate, improved synthesis of this inhibitor was established …

Aromatase catalyzes the conversion of androgens to estrogens through three sequential
oxygenations. To gain insight into the catalytic function of aromatase and its aromatization …

The mechanism of action, pharmacology, and clinical efficacy and safety of exemestane in
the treatment of metastatic breast cancer are reviewed. Endocrine strategies that deprive …

ne of the main pathways of alkane functionalization is their oxidation. In the living nature, this
problem has been successfully solved in two ways: through aerobic oxidation, which …