Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - academic.oup.com
The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …
[HTML][HTML] Fructose, weight gain, and the insulin resistance syndrome
This review explores whether fructose consumption might be a contributing factor to the
development of obesity and the accompanying metabolic abnormalities observed in the …
development of obesity and the accompanying metabolic abnormalities observed in the …
[HTML][HTML] Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins
EA Fisher, HN Ginsberg - Journal of Biological Chemistry, 2002 - ASBMB
Apolipoprotein B100 (apoB100) is expressed primarily in mammalian liver. It has 4536
amino acids, 25 cysteines (16 of which are in intramolecular disulfide bonds), and 20 N …
amino acids, 25 cysteines (16 of which are in intramolecular disulfide bonds), and 20 N …
[HTML][HTML] Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance: evidence that chronic fructose feeding in …
M Haidari, N Leung, F Mahbub, KD Uffelman… - Journal of Biological …, 2002 - ASBMB
Insulin-resistant states are characterized by hypertriglyceridemia, predominantly because of
overproduction of hepatic very low density lipoprotein particles. The additional contribution …
overproduction of hepatic very low density lipoprotein particles. The additional contribution …
[HTML][HTML] Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine …
C Taghibiglou, F Rashid-Kolvear… - Journal of Biological …, 2002 - ASBMB
A fructose-fed hamster model of insulin resistance was previously documented to exhibit
marked hepatic very low density lipoprotein (VLDL) overproduction. Here, we investigated …
marked hepatic very low density lipoprotein (VLDL) overproduction. Here, we investigated …
Dyslipidemia of the metabolic syndrome
G Ruotolo, BV Howard - Current cardiology reports, 2002 - Springer
The three major components of dyslipidemia associated with the metabolic syndrome are
increased fasting and post-prandial triglyceride-rich lipoproteins (TRLs), decreased high …
increased fasting and post-prandial triglyceride-rich lipoproteins (TRLs), decreased high …
Atorvastatin treatment induced peroxisome proliferator-activated receptor α expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose …
N Roglans, E Sanguino, C Peris, M Alegret… - … of Pharmacology and …, 2002 - ASPET
We aimed to investigate the effect of atorvastatin (5 and 30 mg/kg/day for 2 weeks) on
hepatic lipid metabolism in a well established model of dietary hypertriglyceridemia, the …
hepatic lipid metabolism in a well established model of dietary hypertriglyceridemia, the …
Hepatic expression of microsomal triglyceride transfer protein and in vivo secretion of triglyceride-rich lipoproteins are increased in obese diabetic mice
ED Bartels, M Lauritsen, LB Nielsen - Diabetes, 2002 - Am Diabetes Assoc
Secondary hyperlipidemia is a major cardiovascular risk factor in individuals with type 2
diabetes. Increased hepatic production of apolipoprotein B (apoB)-containing lipoproteins …
diabetes. Increased hepatic production of apolipoprotein B (apoB)-containing lipoproteins …
[HTML][HTML] Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density …
A Carpentier, C Taghibiglou, N Leung, L Szeto… - Journal of Biological …, 2002 - ASBMB
To determine whether reduction of insulin resistance could ameliorate fructose-induced very
low density lipoprotein (VLDL) oversecretion and to explore the mechanism of this effect …
low density lipoprotein (VLDL) oversecretion and to explore the mechanism of this effect …
Early kinetic abnormalities of apoB-containing lipoproteins in insulin-resistant women with abdominal obesity
F Pont, L Duvillard, E Florentin, P Gambert… - … , and vascular biology, 2002 - Am Heart Assoc
Objective—The kinetic abnormalities of apolipoprotein B (apoB)-containing lipoproteins in
abdominally obese insulin-resistant individuals remain poorly understood. To determine the …
abdominally obese insulin-resistant individuals remain poorly understood. To determine the …