Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …

The immune system generally avoids horror autotoxicus or autoimmunity, an attack against
the body's own constituents. This avoidance requires that self-reactive T cells be actively …

Natural killer T (NKT) lymphocytes mediate a rapid reaction to the glycolipid drug α-
galactosylceramide (αGalCer), which triggers release of large amounts of cytokines into the …

Peripheral immune tolerance is believed to be induced by the processing and presentation
of self-tissues that die during physiologic tissue turnover. To examine the mechanism that …

Despite the established role of dendritic cells (DCs) in regulating T lymphocyte activation,
intracellular mechanisms responsible for controlling DC function are largely undefined …

Recently, it has become clear that dendritic cells (DCs) are essential for the priming of T cell
responses. However, their role in the maintenance of peripheral T cell tolerance remains …

Interactions between 4‐1BB and its ligand, 4‐1BBL, enhance CD8+ T cell‐mediated
antiviral and antitumor immunity in vivo. However, mechanisms regulating the priming of …

Immunization with DNA followed by modified vaccinia virus Ankara strain, both expressing
the antigen 85A, induced both CD4+-and CD8+-T-cell responses in BALB/c mice. Following …

Immature bone marrow–derived myeloid dendritic cells (BMDCs) are induced to undergo
phenotypic maturation and secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL …

Recently, human dendritic cells (DCs) pulsed with mRNA encoding a broad range of tumor
antigens have proven to be potent activators of a primary anti–tumor-specific T-cell response …