Time in the biological sense is measured by cycles that range from milliseconds to years.
Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most …

In this era of jet travel, our body'remembers' the previous time zone, such that when we
travel, our sleep–wake pattern, mental alertness, eating habits and many other physiological …

Mammalian circadian rhythms are generated by a feedback loop in which BMAL1 and
CLOCK, players of the positive limb, activate transcription of the cryptochrome and period …

The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here
that mice deficient in the mPer2 gene are cancer prone. After γ radiation, these mice show a …

The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus has been referred to
as the master circadian pacemaker that drives daily rhythms in behavior and physiology …

The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and
behavioural processes in mammals. Here we show that prokineticin 2 (PK2), a cysteine-rich …

Circadian rhythmicity in mammals is under the control of a molecular pacemaker constituted
of clock gene products organized in transcriptional autoregulatory loops. Phase resetting of …

The neuropeptides pituitary adenylate cyclase-activating polypeptide (PACAP) and
vasoactive intestinal peptide (VIP) are implicated in the photic entrainment of circadian …

Investigations using the fruit fly Drosophila melanogaster have shown that the circadian
clock gene period (Per) can influence behavioral responses to cocaine. Here we show that …

The core oscillator generating circadian rhythms in eukaryotes is composed of transcription–
translation‐based autoregulatory feedback loops in which clock gene products negatively …