Cellular BCL-2-related proteins (cBCL-2s) function as regulators of programmed cell death
(apoptosis), in part by modulating the release of proapoptotic signaling molecules from …

African swine fever (ASF) is caused by an icosahedral, complex DNA virus classified as the
only member of the family Asfarviridae and the genus Asfivirus (Murphy et al. 1999). ASF is a …

Herpesviruses and poxviruses are known to encode the DNA repair enzyme uracil-DNA
glycosylase (UNG), an enzyme involved in the base excision repair pathway that specifically …

Protective immunity to African swine fever virus (ASFV) may involve a combination of both
serological and cellular mechanisms. This work is focused on the identification of the …

African swine fever virus (ASFV), a complex enveloped DNA virus, expresses two
polyprotein precursors, pp220 and pp62, which after proteolytic processing give rise to …

Presented here is the development a semi-rational protein engineering approach that uses
information from protein structure coupled with established DNA manipulation techniques to …

African swine fever (ASF) and classical swine fever (CSF) are Office International des
Epizooties (OIE)''List A''diseases [1]. This list comprises 15 diseases and represents the most …

African swine fever virus (ASFV) polyprotein pp220, encoded by the CP2475L gene, is an N-
myristoylated precursor polypeptide that, after proteolytic processing, gives rise to the major …

African swine fever virus (ASFV) encodes a homologue of the inhibitor of apoptosis (IAP)
that promotes cell survival by controlling the activity of caspase-3. Here we show that ASFV …

Permissive Vero cells develop apoptosis, as characterized by DNA fragmentation, caspases
activation, cytosolic release of mitochondrial cytochrome c, and flow cytometric analysis of …