Studies on lactulose formulations for colon-specific drug delivery
M Katsuma, S Watanabe, H Kawai, S Takemura… - International Journal of …, 2002 - Elsevier
A novel, colon-targeted delivery system (CODES™), which uses lactulose, was investigated
in this study. Lactulose is not absorbed in the upper GI tract, but degraded to organic acids …
in this study. Lactulose is not absorbed in the upper GI tract, but degraded to organic acids …
Comparison of the mechanical destructive force in the small intestine of dog and human
M Kamba, Y Seta, A Kusai, K Nishimura - International journal of …, 2002 - Elsevier
The purpose of this study was to evaluate the destructive force that oral solid dosage forms
receive in the small intestine of dogs and humans. Information on the mechanical destructive …
receive in the small intestine of dogs and humans. Information on the mechanical destructive …
Lectin-mediated drug delivery: influence of mucin on cytoadhesion of plant lectins in vitro
M Wirth, K Gerhardt, C Wurm, F Gabor - Journal of controlled release, 2002 - Elsevier
As the mucous layer represents the first barrier to peroral lectin-mediated drug delivery, the
influence of mucin on the cytoadhesive properties of lectins was studied in vitro by …
influence of mucin on the cytoadhesive properties of lectins was studied in vitro by …
Variability in cimetidine absorption and plasma double peaks following oral administration in the fasted state in humans: correlation with antral gastric motility
N Takamatsu, LS Welage, Y Hayashi… - European journal of …, 2002 - Elsevier
The role of gastrointestinal motility and pH in determining cimetidine bioavailability as well
as double peaks in plasma profiles following oral administration, in the quiescent or active …
as double peaks in plasma profiles following oral administration, in the quiescent or active …
Evaluation of gastrointestinal solubilization of petroleum hydrocarbon residues in soil using an in vitro physiologically based model
HYN Holman, R Goth-Goldstein, D Aston… - … science & technology, 2002 - ACS Publications
Petroleum hydrocarbon residues in weathered soils may pose risks to humans through the
ingestion pathway. To understand the factors controlling their gastrointestinal (GI) …
ingestion pathway. To understand the factors controlling their gastrointestinal (GI) …
The role of pharmacokinetics in drug discovery: finding drug candidates with the greatest potential for success
JH Lin - Pharmacokinetic Challenges in Drug Discovery, 2002 - Springer
Searching for new drugs is an extremely time-consuming and costly endeavor. Much of the
time and cost is expended on clinical studies to obtain efficacy and safety data. Many drug …
time and cost is expended on clinical studies to obtain efficacy and safety data. Many drug …
Absorption
Y Kwon - … pharmacodynamics and drug metabolism for industrial …, 2002 - Springer
For drugs orally dosed in solid dosage forms such as tablets or capsules, there are two
distinctive processes during absorption: dissolution of solid drug particles to drug molecules …
distinctive processes during absorption: dissolution of solid drug particles to drug molecules …
Animal Physiology
Y Kwon - … Pharmacodynamics and Drug Metabolism for Industrial …, 2002 - Springer
A thorough understanding of animal physiology is a prerequisite for conducting
pharmacokinetic studies and interpreting data in an appropriate way. This chapter presents …
pharmacokinetic studies and interpreting data in an appropriate way. This chapter presents …