To understand the success or failure of immune responses against pathogens or tumours
requires the direct measurement of specific lymphocytes. Recently, there has been an …

Hepatitis C virus (HCV) is an RNA virus which is estimated to persistently infect about 170
million people worldwide. After acute infection, there is an initial period during which long …

CD1d-restricted natural killer (NK) T cells are known to potently secrete T helper (Th) 1 and
Th2 cytokines and to mediate cytolysis, but it is unclear how these contrasting functional …

CD1d-restricted autoreactive natural killer (NK) T cells have been reported to regulate a
range of disease conditions, including type I diabetes and immune rejection of cancer …

Background & Aims: Natural killer T (NKT) cells are a subset of lymphocytes incriminated in
playing an important role in the modulation of the innate immune response and the …

CD1d-restricted NKT cells express an invariant TCR and have been demonstrated to play
an important regulatory role in a variety of immune responses. Invariant NKT cells down …

Human CD1d molecules present an unknown ligand, mimicked by the synthetic
glycosphingolipid α-galactosylceramide (αGC), to a highly conserved NKT cell subset …

Murine intrahepatic lymphocytes (IHL) are dominated by invariant TCR α-chain expressing
CD1d-reactive NKT cells, which can cause model hepatitis. Invariant NKT (CD56+ …

Natural killer T (NKT) cells have become a major focus for those who study the innate
immune response to tumors and infectious diseases, as well as autoimmunity. These novel …

Most CD1d-dependent NKT cells in mice have a canonical Vα14Jα18 TCR rearrangement.
However, relatively little is known concerning the molecular basis for their reactivity to …