The membrane transferrin receptor-mediated endocytosis or internalization of the complex
of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake …

Non-viral gene delivery systems have the potential to create viable pharmaceuticals from
nucleic acids. These DNA delivery systems contain lipids and/or cationic polymers. In order …

Nanoparticles formulated from biodegradable polymers such as poly (lactic acid) and poly
(d, l-lactide-co-glycolide)(PLGA) are being extensively investigated as non-viral gene …

Chitosan (CS)–poly (acrylic acid)(PAA) complex nanoparticles, which are well dispersed
and stable in aqueous solution, have been prepared by template polymerization of acrylic …

Purpose. The objective of this study was to evaluate the extent and mechanism of uptake of
fluorescent chitosan nanoparticles by the A549 cells, a human cell line derived from the …

The ability of a vector to ferry gene into targeted cells is the premise of improving gene-
transfer efficiency. Chitosan, a naturally occurring cationic polysaccharide, has been shown …

Previous studies on chitosan‐insulin nanoparticles have reported diverse encapsulation
efficiency and insulin release profiles despite similar formulation and preparation …

A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate,
comprising the interstitial introduction of an isolated polynucleotide into a tissue of the …

A new cationic polymer (PPA–SP), polyphosphoramidate bearing spermidine side chain,
was prepared as a non-viral vector for gene delivery. PPA–SP was synthesized from poly (1 …

We introduce an injectable system for the formation of a biodegradable DNA-containing
implant that releases DNA over a 2-month period to provide a robust and prolonged gene …