This review addresses novel concepts of histamine H1‐receptor function and attempts to
relate them to the anti‐inflammatory effects of H1‐antihistamines. Furthermore, the …

The release of transmitters at sympathoeffector junctions is not constant, but subject to
modulation by a plethora of different mechanisms. In this respect, presynaptic receptors …

Dorsal raphe serotonin neurons fire tonically at a low rate during waking. In vitro, however,
they are not spontaneously active, indicating that afferent inputs are necessary for tonic …

The detailed distribution of histamine H3 receptor mRNAs in rat brain was analyzed by in
situ hybridization using a 33P-labelled riboprobe and was combined for the first time with the …

Competition experiments with [3H] mepyramine showed that cetirizine and its enantiomers,
levocetirizine and (S)-cetirizine, bound with high affinity and stereoselectivity to human H1 …

Brain histamine H3 receptors are predominantly presynaptic and serve an important
autoregulatory function for the release of histamine and other neurotransmitters. They have …

We have characterized desloratadine (5H-benzo [5, 6] cyclohepta [1, 2-b] pyridine, 8-chloro-
6, 11-dihydro-11-(4-piperidinylidene), CAS 100643-71-8) as a potent antagonist of the …

Constitutive activity of the recombinant and native rat and human H3 receptors (H3Rs) was
studied using H3R‐mediated [35S] GTPγ [S] binding and [3H]‐arachidonic acid release …

Background: Histamine is a well-known mediator eliciting different responses in immune
and nonimmune cells, but its role in modulating dendritic cell (DC) functions has been …

The monoamine histamine is an important chemical messenger that regulates a wide variety
of physiological responses in the brain and peripheral organs. In the central nervous system …