The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

J Hardy, DJ Selkoe - science, 2002 - science.org
It has been more than 10 years since it was first proposed that the neurodegeneration in
Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques …

Toxic proteins in neurodegenerative disease

JP Taylor, J Hardy, KH Fischbeck - science, 2002 - science.org
A broad range of neurodegenerative disorders is characterized by neuronal damage that
may be caused by toxic, aggregation-prone proteins. As genes are identified for these …

[图书][B] Энергетическая физиология мозга

ВФ Фокин, НВ Пономарева - 2002 - elibrary.ru
Энергетическая физиология мозга КОРЗИНА ПОИСК НАВИГАТОР ЖУРНАЛЫ КНИГИ
ПАТЕНТЫ ПОИСК АВТОРЫ ОРГАНИЗАЦИИ КЛЮЧЕВЫЕ СЛОВА РУБРИКАТОР …

Amyloid precursor protein, presenilins, and α-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease

YH Suh, F Checler - Pharmacological reviews, 2002 - ASPET
Alzheimer's disease (AD) is the most common cause of dementia that arises on a
neuropathological background of amyloid plaques containing β-amyloid (Aβ) derived from …

γ-Secretase, Notch, Aβ and Alzheimer's disease: where do the presenilins fit in?

SS Sisodia, PH St George-Hyslop - Nature Reviews Neuroscience, 2002 - nature.com
Investigations into the proteolytic processing of amyloid precursor protein (APP) have
provided insights into both the pathogenesis of Alzheimer's disease and an unusual form of …

Does caffeine intake protect from Alzheimer's disease?

L Maia, A De Mendonça - European journal of neurology, 2002 - Wiley Online Library
Caffeine is the most widely consumed behaviourally active substance in the western world.
Neuroprotective effects of caffeine in low doses, chronically administered, have been shown …

A novel ϵ-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

A Weidemann, S Eggert, FBM Reinhard, M Vogel… - Biochemistry, 2002 - ACS Publications
Proteolytic processing of the transmembrane domain of the amyloid precursor protein (APP)
is a key component of Alzheimer's disease pathogenesis. Using C-terminally tagged APP …

Deciphering the genetic basis of Alzheimer's disease

DJ Selkoe, MB Podlisny - Annual review of genomics and …, 2002 - annualreviews.org
A remarkable rise in life expectancy during the past century has made Alzheimer's disease
(AD) the most common form of progressive cognitive failure in humans. Compositional …

Age at onset in two common neurodegenerative diseases is genetically controlled

YJ Li, WK Scott, DJ Hedges, F Zhang… - The American Journal of …, 2002 - cell.com
To identify genes influencing age at onset (AAO) in two common neurodegenerative
diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; …

Genetically engineered mouse models of neurodegenerative diseases

PC Wong, H Cai, DR Borchelt, DL Price - Nature neuroscience, 2002 - nature.com
Recent research has significantly advanced our understanding of the molecular
mechanisms of neurodegenerative diseases, including Alzheimer's disease (AD) and motor …