The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
It has been more than 10 years since it was first proposed that the neurodegeneration in
Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques …
Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques …
Toxic proteins in neurodegenerative disease
JP Taylor, J Hardy, KH Fischbeck - science, 2002 - science.org
A broad range of neurodegenerative disorders is characterized by neuronal damage that
may be caused by toxic, aggregation-prone proteins. As genes are identified for these …
may be caused by toxic, aggregation-prone proteins. As genes are identified for these …
[图书][B] Энергетическая физиология мозга
ВФ Фокин, НВ Пономарева - 2002 - elibrary.ru
Энергетическая физиология мозга КОРЗИНА ПОИСК НАВИГАТОР ЖУРНАЛЫ КНИГИ
ПАТЕНТЫ ПОИСК АВТОРЫ ОРГАНИЗАЦИИ КЛЮЧЕВЫЕ СЛОВА РУБРИКАТОР …
ПАТЕНТЫ ПОИСК АВТОРЫ ОРГАНИЗАЦИИ КЛЮЧЕВЫЕ СЛОВА РУБРИКАТОР …
Amyloid precursor protein, presenilins, and α-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease
Alzheimer's disease (AD) is the most common cause of dementia that arises on a
neuropathological background of amyloid plaques containing β-amyloid (Aβ) derived from …
neuropathological background of amyloid plaques containing β-amyloid (Aβ) derived from …
γ-Secretase, Notch, Aβ and Alzheimer's disease: where do the presenilins fit in?
SS Sisodia, PH St George-Hyslop - Nature Reviews Neuroscience, 2002 - nature.com
Investigations into the proteolytic processing of amyloid precursor protein (APP) have
provided insights into both the pathogenesis of Alzheimer's disease and an unusual form of …
provided insights into both the pathogenesis of Alzheimer's disease and an unusual form of …
Does caffeine intake protect from Alzheimer's disease?
L Maia, A De Mendonça - European journal of neurology, 2002 - Wiley Online Library
Caffeine is the most widely consumed behaviourally active substance in the western world.
Neuroprotective effects of caffeine in low doses, chronically administered, have been shown …
Neuroprotective effects of caffeine in low doses, chronically administered, have been shown …
A novel ϵ-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing
A Weidemann, S Eggert, FBM Reinhard, M Vogel… - Biochemistry, 2002 - ACS Publications
Proteolytic processing of the transmembrane domain of the amyloid precursor protein (APP)
is a key component of Alzheimer's disease pathogenesis. Using C-terminally tagged APP …
is a key component of Alzheimer's disease pathogenesis. Using C-terminally tagged APP …
Deciphering the genetic basis of Alzheimer's disease
DJ Selkoe, MB Podlisny - Annual review of genomics and …, 2002 - annualreviews.org
A remarkable rise in life expectancy during the past century has made Alzheimer's disease
(AD) the most common form of progressive cognitive failure in humans. Compositional …
(AD) the most common form of progressive cognitive failure in humans. Compositional …
Age at onset in two common neurodegenerative diseases is genetically controlled
To identify genes influencing age at onset (AAO) in two common neurodegenerative
diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; …
diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; …
Genetically engineered mouse models of neurodegenerative diseases
Recent research has significantly advanced our understanding of the molecular
mechanisms of neurodegenerative diseases, including Alzheimer's disease (AD) and motor …
mechanisms of neurodegenerative diseases, including Alzheimer's disease (AD) and motor …