There is growing evidence that the development of naı̈ve B cells depends on the
interaction of self antigens with the BCR. A view that has emerged over the past year is that …

These studies characterize BLyS responsiveness and receptor expression among
transitional and mature peripheral B cells. The results show a maturation-associated …

Signaling through the Ag receptor is required for peripheral B lymphocyte maturation and
maintenance. Defects in components of the B cell receptor (BCR) signalosome result in …

Mature B-lymphocytes develop sequentially from transitional type 1 (T1) and type 2 (T2)
precursors in the spleen. To elucidate the mechanisms that regulate the developmental fate …

In this essay, I make four points about the operation of the immune system. First, thanks to
the innate immune system's regulation of the main costimulatory molecules CD80 and …

We have defined roles for the hemopoietic-specific Rho guanosine triphosphatase, Rac2, in
B lymphocyte development and function through examination of rac2−/− mice. Rac2 …

It is well established that autoreactive B cells undergo negative selection. This stands in
paradox with the high frequency of so-called natural autoreactive B cells producing low …

B Lymphocyte Stimulator (BLyS™ 3; protein) is a member of the tumor necrosis factor (TNF)
family of ligands and functions as an essential in vivo regulator of B lymphocyte …

As the largest secondary lymphoid organ, the spleen has a number of important roles in the
immune response, including the clearance of effete or damaged cells from the bloodstream …

B cell receptor signaling threshold regulates negative selection of autoreactive B cells and
determines the mechanism of B cell tolerance. Using mice carrying immunoglobulin …