Considerations for successful transplantation of encapsulated pancreatic islets

P De Vos, AF Hamel, K Tatarkiewicz - Diabetologia, 2002 - Springer
Encapsulation of pancreatic islets allows for transplantion in the absence of
immunosuppression. The technology is based on the principle that transplanted tissue is …

Encapsulation of pancreatic islets for transplantation in diabetes: the untouchable islets

P de Vos, P Marchetti - Trends in molecular medicine, 2002 - cell.com
The aim of encapsulation of pancreatic islets is to transplant in the absence of
immunosuppression. It is based on the principle that transplanted tissue is protected from …

Chemistry and biocompatibility of alginate‐PLL capsules for immunoprotection of mammalian cells

P de Vos, CG Hoogmoed… - Journal of Biomedical …, 2002 - Wiley Online Library
Transplantation of encapsulated living cells is a promising approach for the treatment of a
wide variety of diseases. Large‐scale application of the technique, however, is hampered by …

Flow properties of liquid calcium alginate polymer injected through medical microcatheters for endovascular embolization

TA Becker, DR Kipke - … Research: An Official Journal of The …, 2002 - Wiley Online Library
The flow properties of liquid calcium alginate injections were investigated for application in
endovascular embolization. Alginate shear properties were assessed with a rheometer and …

In vitro and in vivo evaluation of alginate/sol–gel synthesized aminopropyl-silicate/alginate membrane for bioartificial pancreas

S Sakai, T Ono, H Ijima, K Kawakami - Biomaterials, 2002 - Elsevier
Alginate/aminopropyl-silicate/alginate (Alg/AS/Alg) membrane was prepared on Ca-alginate
gel beads by a sol–gel process. The membrane has≡ Si–O–Si≡ bonds as well as …

Tissue responses against immunoisolating alginate‐PLL capsules in the immediate posttransplant period

P De Vos, CG van Hoogmoed… - … Research: An Official …, 2002 - Wiley Online Library
Alginate‐polylysine (PLL) capsules are commonly applied for immunoisolation of living cells
for the treatment of a wide variety of diseases. Large‐scale application of the technique …

Analyte flux through chronically implanted subcutaneous polyamide membranes differs in humans and rats

N Wisniewski, N Rajamand… - American Journal …, 2002 - journals.physiology.org
The rat is commonly used to evaluate physiological responses of subcutaneous tissue to
implanted devices. In vivo longevity of various devices and the biocompatibility of …

Effect of cross-linked hemoglobin on functionality and viability of microencapsulated pancreatic islets

SY Chae, SW Kim, YH Bae - Tissue Engineering, 2002 - liebertpub.com
Of many obstacles involved in developing a bioartificial pancreas, which consists of
encapsulated and physically immunoprotected islets, for long-term implantation in insulin …

MTS Colorimetric Assay in Combination with a Live‐Dead Assay for Testing Encapsulated L929 Fibroblasts in Alginate Poly‐l‐Lysine Microcapsules In Vitro

CM Bünger, A Jahnke, J Stange, P De Vos… - Artificial …, 2002 - Wiley Online Library
Biomaterials such as applied in microcapsules may have harmful effects on encapsulated
cells. Up to now, there are no adequate assays available for testing the function and viability …

Processing of immunoisolated pancreatic islets: implications for histological analyses of hydrated tissue

BJ De Haan, H van Goor, P De Vos - Biotechniques, 2002 - Taylor & Francis
Routine tissue processing is usually associated with histological artifacts as a consequence
of shrinkage and distortion during dehydration required for embedding. With hydrated …